Some examples include tramadol (Ultram, ConZip), codeine, oxycodone (Oxycontin, Roxicodone, others) and hydrocodone (Hysingla ER). Narcotic medications are used mainly to relieve severe symptoms, but they may be addicting if used in high doses. These medications are generally only used if no other treatment provides relief. These drugs help you sleep better at night, but they don't eliminate the leg sensations, and they may cause daytime drowsiness. Muscle relaxants and sleep medications.Certain medications, such as gabapentin (Neurontin, Gralise), gabapentin enacarbil (Horizant) and pregabalin (Lyrica), work for some people with RLS. However, they can also cause impulse control disorders, such as compulsive gambling, and daytime sleepiness. Short-term side effects of these medications are usually mild and include nausea, lightheadedness and fatigue. Rotigotine (Neupro) and pramipexole (Mirapex) are approved by the Food and Drug Administration for the treatment of moderate to severe RLS. These medications affect levels of the chemical messenger dopamine in the brain. Medications that increase dopamine in the brain. Several prescription medications, most of which were developed to treat other diseases, are available to reduce the restlessness in the legs. If those aren't effective, your provider might prescribe medications. If you have RLS without an associated condition, treatment focuses on lifestyle changes. However, take iron supplements only with medical supervision and after your provider has checked your blood-iron level. Correcting an iron deficiency may involve receiving iron supplementation orally or intravenously.
Sometimes, treating an underlying condition, such as iron deficiency, greatly relieves symptoms of RLS.
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